Refissa is a prescription grade retin-a cream, formulated with a built-in moisturizer so even the most sensitive skin can tolerate regular use. The consistent use of retin-a helps with exfoliation, smoothing fine lines and wrinkles, diminishing pore size, decreasing dark spots and with continued use, increasing skin thickness. Retin-a is the gold standard and should be the basis of all anti-aging skin care regimens.